Photochemical Oxidation of Bilirubin to Biliverdin

Bilirubin and biliverdin binding to rat Y protein (ligandin).

The binding of bilirubin to poly(L-lysine) produces an optically active complex at pH 10.1. Circular dichroism spectra of these complexes are distinguishable from those generated by binding of bilirubin to the high affinity sites on albumin. Comparison of the circular dichroism spectra of bilirubin bound to the hepatic protein ligandin with those of bilirubin complexed with albumin or polylysin...

Direct Antioxidant Properties of Bilirubin and Biliverdin. Is there a Role for Biliverdin Reductase?

Reactive oxygen species (ROS) and signaling events are involved in the pathogenesis of endothelial dysfunction and represent a major contribution to vascular regulation. Molecular signaling is highly dependent on ROS. But depending on the amount of ROS production it might have toxic or protective effects. Despite a large number of negative outcomes in large clinical trials (e.g., HOPE, HOPE-TOO...

Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle.

Great Britain Synthesis of Biliverdin and Bilirubin 1 - O - Acyl - fJ - D - glucGpyranuronic Acids

Biliverdin and bilirubin monoand di-JJ-glucuronides were prepared by nucleophilic substitution of the 1-O-mesyl derivative of a-ethoxyethyl-protected glucuronic acid (compound II) with the tetrabutylammonium salts of biliverdin apd bilirubin. Removal of the acetal-protecting groups by mild acid treatment yielded biliverdin glucuronides, which were reduced to bilirubin glucuronides. Depending on...

Studies on the Chemical and Photochemical Oxidation of Bacteriochlorophyll